Sialyl-lewis x
WebJan 22, 2015 · Cell adhesion via selectins also results in signaling that may contribute to integrin activation and the transition of rolling cells to firm arrest. 3,4 The sialofucosylated glycans that bind all 3 selectins include the tetrasaccharide sialyl Lewis-X (sLe X) and related structures. 5,6 Although many cell-surface glycoconjugates express such ... WebStructures of sialyl Lewis x (sLe x) and sialyl Lewis a (sLe a). Selectins bind to glycans with a terminal tetrasaccharide structure known as sialyl Lewis x/a. The core of the terminal tetrasaccharide is a disaccharide of galactose linked to N-acetylglucosamine (GlcNAc), either in α1,4 (sLe x) or α1,3 (sLe a) linkage.
Sialyl-lewis x
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WebFeb 15, 2024 · The sialyl Lewis x (sLe x) reviewed in this paper is a derivative of the Lewis blood group antigen structure, also is a surface glycan. The monofucosyl substitution of the type 2 chain and α2,3-sialylation result in the formation of sLe x antigen . WebAug 18, 2011 · The high density of sialyl-Lewis x antennae observed on the ZP N-glycans was unusual. Examples of multivalent sialyl-Lewis x N-glycans are displayed in Fig. 3. …
WebNov 4, 2024 · Trinchera, M., Aronica, A. & Dall’Olio, F. Selectin ligands sialyl-lewis a and sialyl-lewis x in gastrointestinal cancers. Biology 6 , 16 (2024). Article PubMed Central Google Scholar WebG. Kretzschmar is an academic researcher. The author has contributed to research in topic(s): Sialyl-Lewis X & Oligosaccharide. The author has an hindex of 1, co-authored 3 publication(s) receiving 60 citation(s).
WebMay 31, 2024 · BackgroundLewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are … Web(1) Led research that identified sialyl Lewis-X as a novel cell surface glycan marker of human hematopoietic stem cells.-- Multi-parameter flow cytometry assays to purify novel subsets of human ...
WebAug 15, 1995 · After removal of sialic acids, most of the mucins rich in sialyl-Lewis(a) and sialyl-Lewis(x) oligosaccharides no longer bound to a DEAE-cellulose column at pH 8.0. These results indicate that at least part of the sialyl-Lewis(a) and sialyl-Lewis(x) in SW1990 cells is associated with the MUC1 polypeptide.
Sialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The studies done on these individuals' red … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the … See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes" See more crystal nails palm harbor flWebOct 21, 2024 · The impact of glycosylation on cell behavior largely depends on the terminal portions of glycoconjugates. Examples of terminal structures include α2,3- and α2,6-linked … crystal nail spa st petersburg flWebSialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin). Sialyl-Lewis X … dxghw48p