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Erdheim–Chester disease (ECD) is an extremely rare disease characterized by the abnormal multiplication of a specific type of white blood cells called histiocytes, or tissue macrophages (technically, this disease is termed a non-Langerhans-cell histiocytosis). It was declared a histiocytic neoplasm by the World … Visa mer Long bone involvement is almost universal in ECD patients and is bilateral and symmetrical in nature. More than 50% of cases have some sort of extraskeletal involvement. This can include kidney, skin, brain and lung … Visa mer Erdheim–Chester disease was previously associated with high mortality rates. However, long-term survival is now more promising. Recent studies have reported that some patients … Visa mer Approximately 500 cases had been reported in the literature as of 2014. ECD affects predominantly adults, with a mean age of 53 years. Visa mer The Erdheim–Chester Disease Global Alliance is a support and advocacy group with the goal of raising awareness of and promoting research … Visa mer Radiologic osteosclerosis and histology are the main diagnostic features. Diagnosis can often be difficult because of the rareness of ECD as … Visa mer There are two FDA-approved targeted drugs to treat ECD. • Vemurafenib, an oral agent approved in 2024, targets the BRAF protein. It was approved after showing dramatic efficacy in ECD patients harboring the BRAF V600E mutation. Visa mer The first case of ECD was reported by the American pathologist William Chester in 1930, during his visit to the Austrian pathologist Jakob Erdheim in Vienna. Visa mer WebbFor the past decade, I have investigated the eye movement abnormalities associated with various neurological diseases, movement disorders, and traumatic brain injury. We have identified unique ... solano county science fair
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