WebMay 22, 2013 · INCB-9471 is a selective, reversible, small-molecule CCR5 coreceptor antagonist that binds to a CCR5 binding pocket that is different from what maraviroc binds to. INCB-9471prevents viral entry by inhibiting the interaction between HIV-1 gp120 and CCR5. INCB-9471 prevents CCR5-mediated viral entry via allosteric noncompetitive … WebTato studie vyhodnocuje bezpečnost, farmakokinetiku a účinnost antagonisty CCR5 INCB009471 u pacientů infikovaných HIV-1, kteří dosud neužívali ... Registr klinických hodnocení. ICH GCP.
A Randomized, Double-blind, Placebo-controlled Study Exploring …
Development of new CCR5 antagonists continues, both for their antiviral effects and also for potential utility in a variety of autoimmune indications. Researchers at Roche Palo Alto discovered a novel series of potent CCR5 small-molecule antagonists. Lead optimization was pursued by balancing opposing trends of metabolic stability and potency. Combination of the spiropiperidine template w… Web--The safety/activity of other once-daily doses of INCB009471 is under investigation--Phase 2b studies are planned of one (or more) doses Background Information: INCB9471 … eastchester fish house
Safety/Effectiveness of Oral Chemokine Coreceptor 5 (CCR5) …
WebINCB 9471 Alternative Names: INCB009471; INCB9471 Latest Information Update: 02 Oct 2024 Price : $50 * Buy Profile Adis is an information provider. We do not sell or distribute … WebSafety/Effectiveness of Oral Chemokine Coreceptor 5 (CCR5) Antagonist INCB009471 in R5-Tropic HIV Infected Patients : Official Title: A Randomized, Double-Blind, Placebo-Controlled Study Exploring the Safety, Tolerability, PK & Virological Effect of Once Daily Oral Dosing of INCB009471 as Monotherapy for 14 Days in ARV-naïve/Limited ARV ... WebSubjects will receive study medication (INCB009471) admnistered orally or placebo once daily with food for 14 days. Clinical safety laboratories, 12-lead electrocardiograms, physical examinations and virologic assessments, including viral load, viral tropism and CD4+ cell count determinations will be performed at the Screening visit and at ... eastchester fireplace