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Web5. Taper with methadone. There are two methods of tapering: a relatively quick method and a more recently prescribed long term method. In both cases, clonidine is often given to … http://medstopper.com/files/StoppingMedicationInTheElderly-ABHBpracticalGuidance_May2013_NHSWales.pdf Web8 feb. 2008 · Often, if a person has been on prednisone for months, the doc may say that once they get to 5 mg, they should stay there a month, then wean to 2.5 mg for a month. If a person weans too fast, they can go into shock. It is very serious. Weaning depends on how long you've been on prednisone and the dosage. hernia cause upset stomach