WebGalectin 4, or GAL-4, is another member of the Galectin family. Galectins are carbohydrate binding proteins that appear important in cell-cell contact, cell migration, and cell to cell signaling in both normal and disease (cancerous) tissues. Galectin 4 differs from its sister family members in the range of carbohydrate substrates that it binds. Web1 day ago · Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer development, progression, and metastasis. This study reports that galectin-3 secretion by human colon cancer cells …
High-affinity binding of recombinant human galectin-4 to SO
WebMar 18, 2024 · Galectins are β-galactoside-binding proteins. Galectin-4 has shown an effect on cancer progression/metastasis, especially in cancers of the digestive system. This … Webpassing the carbohydrate-binding site [2]. Galectin-3 exerts a diversity of functions, depending on its subcellular localization. Cell surface galectin-3 med-iates cell–cell and … plast focus 2022
Sialylation of cell surface glycoconjugates modulates cytosolic ...
WebJan 16, 2024 · In vitro experiments have also shown that IL-4 induces galectin-3 expression and galectin-3 facilitates M2-like macrophage polarization by binding CD98, which … Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer. The 323-amino acid LGALS4 … See more Gal 4 belongs to the family of galectin. Among various structure of galectins like dimeric, tandem or chimera, Gal-4 is tandem in its structure, so they contains at least two distinct carbohydrate recognising domains (CRD) … See more Recommended name:Galectin-4, Short name: Gal-4 Alternative name(s): See more Gal-4 has binding ability with high affinity to lipid rafts suggesting a role in protein delivery to cells Plus they can perform the following Physiological functions: Gal-4 enhances the stabilization of lipid raft See more • Huflejt ME, Jordan ET, Gitt MA, et al. (1997). "Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion" See more Gal-4 is generally found in stomach and intestine. See more Gal-4 and cancer Gal-4 which has been detected in many cancer has involved in association with the development and sequence of pancreatic carcinoma, hepatocellular carcinoma, Colorectal cancer (CRC), breast carcinoma, gastric cancer, … See more WebApr 13, 2024 · Galecto to Present Two Posters at AACR Annual Meeting 2024. BOSTON, April 13, 2024 (GLOBE NEWSWIRE) -- Galecto, Inc. (NASDAQ: GLTO), a clinical-stage … plast compactor