Cytoplasmic phospholipase a2
WebMay 5, 2005 · Introduction. Lipid requirements of the mammal are met by dietary intake and de novo synthesis; the omega-6 fatty acids (ω-6 FAs) are essential since they cannot be synthesized by mammals and must be supplied in the diet. Linoleic acid (LA) and its product, arachidonic acid (AA) are transformed into prostaglandins (PG) and thromboxanes (TX) … WebOct 1, 2005 · Here we describe that AA induces expression of cytosolic phospholipase A2 (cPLA2) in a dose-dependent manner and that this upregulation is dependent upon downstream synthesis of PGE2.
Cytoplasmic phospholipase a2
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WebRecent studies have suggested that abnormal lipid metabolism, inflammatory injury, and dysfunction of the vascular endothelial cells may be centrally linked to HDP. 5,6 Lp-PLA2 is a member of the phospholipase A2 (PLA2) superfamily, with the human gene located on chromosome 6p12-21.1 and consisting of 441 amino acids. 14 It was found that Lp ... WebMany different forms of phospholipase A2 are made for different functions. Secreted phospholipase A2 is small, whereas the cytoplasmic enzymes are larger, with separate domains that are involved with interaction with …
WebOct 8, 2004 · Arachidonic acid is released from membrane phospholipids by phospholipase A2 (PLA2). Several types of PLA2 are expressed in human cells. Among them … WebApr 1, 2005 · In the following study, we evaluated the influence of genetic deletion of a key intracellular phospholipase, cytoplasmic PLA 2 (cPLA 2 ), on azoxymethane-induced colon tumorigenesis.
WebApr 12, 1994 · In addition, the band that corresponds to phospholipase A2 is shifted upward in membrane isolated from neutrophils stimulated with fMet-Leu-Phe, suggesting that the enzyme has been altered, possibly phosphorylated, though not on tyrosine residues. A working hypothesis is presented. WebMar 23, 2005 · Our focus is on the Ca 2+-sensitive form, referred to as cytoplasmic phospholipase A 2 α (cPLA 2 α), which is ubiquitously expressed in most tissues and …
WebDec 7, 2024 · Activation of phospholipase A2 (PLA2) is an essential prerequisite for GPVI stimulated thromboxane A2 (TXA2) generation that induces paracrine platelet activation …
WebMultiple forms of phospholipase A2 may be associated with the production of these metabolites; this study focused on the molecular mechanism(s) by which glucocorticoids control expression of the arachidonyl-selective, … images of painted garage doorsWebDec 8, 2024 · Activation of phospholipase A2 (PLA2) is an essential prerequisite for GPVI stimulated thromboxane A2 (TXA2) generation that induces paracrine platelet activation … list of baby registryWebJan 15, 2000 · The release of labeled AA was studied in parallel to the analysis of cPLA 2 levels and activity. [ 3 H]AA release from prelabeled neutrophils stimulated with 50 ng/mL … list of baby pokemonWebMay 8, 2024 · The supergroup of cytosolic PLA consists of 6 members that each contain 749 amino acids and share other structural similarities. The … list of baby names for boys and girlsWebMay 15, 1993 · Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. PNAS Research Article Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. images of painted built in bookshelvesIncreased phospholipase A 2 has also been associated with neuropsychiatric disorders such as schizophrenia and pervasive developmental disorders (such as autism), though the mechanisms involved are not known. Isozymes. Human phospholipase A 2 isozymes include: Group I: PLA2G1B; Group II: … See more The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the … See more Phospholipases A2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A2. … See more PLA2 action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils. See more In normal brain cells, PLA2 regulation accounts for a balance between arachidonic acid's conversion into proinflammatory mediators and its reincorporation into … See more The suggested catalytic mechanism of pancreatic sPLA2 is initiated by a His-48/Asp-99/calcium complex within the active site. The calcium ion polarizes the sn-2 carbonyl oxygen while also coordinating with a catalytic water molecule, w5. His … See more Due to the importance of PLA2 in inflammatory responses, regulation of the enzyme is essential. cPLA2 is regulated by phosphorylation and calcium concentrations. cPLA2 is phosphorylated by a MAPK at Serine-505. When phosphorylation is … See more Human phospholipase A2 isozymes include: • Group I: PLA2G1B • Group II: PLA2G2A, PLA2G2C, PLA2G2D, PLA2G2E, PLA2G2F • Group III: PLA2G3 See more images of painted cowsWebCytosolic phospholipase A2 antibody; Cytosolic phospholipase A2 group IVA antibody; Lysophospholipase antibody; MGC126350 antibody; PA24A_HUMAN antibody; … list of baby names and their meanings